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All About Synthetic Nicotine

Synthetic Nicotine, Tobacco Free Nicotine, Vape, Vape Juice, Vape Shop, Vaping -

All About Synthetic Nicotine

Whoa, vape fam! You’ve caught me at a crazy time. The boss told me to test all these synthetic nicotine vape products so I can give you the lowdown on what this new and innovative thing called synthetic nicotine. I can tell you a few things myself, but I have to bring back my guest expert to explain the fine details of what this new awesome thing we’re putting in our vape juices.

So there’s this thing called freebase nicotine, right? Vape fam, that’s what you’ve been vaping this entire time! But then someone thought, what if freebase nicotine gets banned? How do we get around this? The short answer is synthetic nicotine. The government isn’t exactly what we’d call cool with this new innovation. They already don’t like the sick flavors we sell on VapeBargains.com for 30% off everyday, so why would they be cool with something like this, right? You see, the FDA wants to put ME on the unemployment line, and running into fans at my next job would be REALLY awkward. We can’t have that happen, right? 

So let’s answer some questions with my good friend Cloud McVape: what is synthetic nicotine? What are the differences between synthetic nicotine and freebase nicotine? Why is synthetic nicotine under the watchful eye of the FDA and other anti-tobacco groups? What brands have made the switch to synthetic nicotine, and what brands are looking to switch in the future? Let’s answer some of these questions.

What Is Synthetic Nicotine?

Synthetic nicotine is defined as nicotine not derived from the tobacco plant, and is also referred to as TFN. While nicotine is derived largely from the tobacco plant, it can also be found in smaller amounts in everyday foods such as tomatoes, green peppers, eggplants, potatoes, cauliflower, and even the coca plant. Synthetic nicotine can be created by scientists in a laboratory without the impurities of freebase (tobacco-derived) nicotine. While some alternative nicotine products already have synthetic nicotine, most vape juices use freebase nicotine, although many vape manufacturers have decided to swap to synthetic nicotine/TFN in the past year.

One company owns the trademark for synthetic nicotine/TFN: Next Generation Labs. They could seek to profit greatly from this switch. According to Vincent Schuman, the CEO of Next Generation Labs, “All indications from the FDA confirm our long-held position: TFN nicotine products cannot be regulated under the Deeming Rule as they are not tobacco products, and we continue to believe that an open or closed system device for use with a choice of synthetic nicotine products will qualify as a non-tobacco product.”

Advantages of Synthetic Nicotine

In addition to not being regulated by the FDA, synthetic nicotine/TFN is purer than freebase nicotine derived from the tobacco plant. Some impurities exist in freebase nicotine, which may affect your vaping experience despite the majority of vape juices using freebase nicotine. By using synthetic nicotine/TFN, which is pure nicotine, it may improve the quality of the vaping experience overall and encourage those who are currently using traditional nicotine products to sample alternative nicotine products containing synthetic nicotine/TFN.


Next Generation Labs has provided a list of advantages of synthetic nicotine, which you can view below.

Find TFN at VapeBargains.com

(Image courtesy of Next Generation Labs)

Why Is It Being Targeted By The FDA?


Your guess is as good as mine, but it seems like the FDA isn’t going to really answer my question, vape fam. I sent them a letter asking why they’re trying to get rid of flavors. They said that it depends. Basically, it’s on a case-by-case basis. The FDA isn’t actually going to regulate this product just yet. “E-liquids that do not contain nicotine or other substances made or derived from tobacco may still be components or parts and, therefore, subject to FDA’s tobacco control authorities,” the FDA has said.


The boss also gave me some “light” reading when I first became the voice of VapeBargains.com, in the form of the Tobacco Control Act of 2009. I’ve read this thing cover to cover, and vaping products are put under the Center for Tobacco Products (CTP). Thankfully, synthetic nicotine isn’t regulated by the FDA (yet), but they could make a switch into regulating it to take out the vape industry. Vape fam, help me keep my job, and tell the man that you love flavors and synthetic nicotine! I’d really appreciate it.


Are Brands Switching to Synthetic Nicotine?

The short answer is yes! Brands are finally seeing the value of synthetic nicotine. Not only do you get a purer vaping experience, but brands are understanding that regulation and legislation is here to stay. It’s a gift and a curse, vape fam. You can see what brands made the switch to synthetic nicotine on our synthetic nicotine collection page. NKTR was one of the first brands to switch to synthetic nicotine, but since then, our friends at Reds Apple eJuice, Air Factory, Noms eJuice, and Cloud Nurdz have all made the switch to synthetic nicotine, with many more following suit.


An example of a previously banned product that made the switch from traditional freebase nicotine to synthetic nicotine/TFN is Puff Bars, a popular disposable vape product. In July 2020, the FDA ordered Puff Bars off the market. Puff Bars returned in 2021 with a revamped formula that used synthetic nicotine/TFN.


We will be updating this page with any further developments about synthetic nicotine/TFN, so check back to make sure that you are up to date with the latest information!









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